DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes - Laboratoire de génétique et biologie cellulaire
Article Dans Une Revue BioEssays Année : 2023

DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes

Résumé

DREAM complexes are transcriptional regulators that control the expression of hundreds to thousands of target genes involved in the cell cycle, quiescence, differentiation, and apoptosis. These complexes contain many subunits that can vary according to the considered target genes. Depending on their composition and the nature of the partners they recruit, DREAM complexes control gene expression through diverse mechanisms, including chromatin remodeling, transcription cofactor and factor recruitment at various genomic binding sites. This complexity is particularly high in mammals. Since the discovery of the first dREAM complex (drosophila Rb, E2F, and Myb) in Drosophila melanogaster, model organisms such as Caenorhabditis elegans, and plants allowed a deeper understanding of the processes regulated by DREAMlike complexes. Here, we review the conservation of these complexes. We discuss the contribution of model organisms to the study of DREAM-mediated transcriptional regulatory mechanisms and their relevance in characterizing novel activities of DREAM complexes.
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hal-04329736 , version 1 (07-12-2023)

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Marion Hoareau, Aurore Rincheval-Arnold, Sébastien Gaumer, Isabelle Guénal. DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes. BioEssays, 2023, 46 (2), ⟨10.1002/bies.202300125⟩. ⟨hal-04329736⟩
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