This article explores the role of the World Health Organization (WHO) within the tumultuous history of the hepatitis B vaccine in France, including a controversy that erupted in 1996 and lasted several years. When the first hepatitis B vaccine was commercialized in France in 1981, it inaugurated a new era in the industry characterized by high prices, an unprecedented number of patents and aggressive commercial competition. By inscribing the hepatitis B vaccine controversy into a broader, global history of the economization of immunization – in which the WHO played a central role – this article reframes the causes and implications of a controversy that both actors and scholars have approached through a primarily national lens. The challenge posed to the economic approach to immunization prepared the ground for subsequent critiques of vaccines as commodities. The article discusses a key transformation in the recent transatlantic history of public health by focusing on the perceived association of immunization with a contested economic order.