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Journal Articles European journal of cancer Year : 2006

Why don’t cancer patients enter clinical trials? A review

Sylvie Négrier
  • Function : Author
Jean-Pierre Boissel
  • Function : Author


Despite wide agreement with the usefulness of clinical trials, the proportion of patients who are enrolled in such trials is often considered as too low. We performed a comprehensive search of the literature from 1980 to the present to review the current data on barriers and facilitators to the development of multicenter clinical trials. Of 364 articles initially identified, we selected 35 articles and one book which main purpose was to assess the reasons of physicians’ and/or patients’ participation in clinical trials. Our review underlines that physicians play a key-role in the development and non-development of clinical trials. More studies – in particular outside the United States – are needed to better understand physicians’ attitudes towards clinical trials. They should combine multivariate analyses and comparative approaches in order to associate physicians’ behaviours with their individual characteristics, with the organisational context of their working environment and with the health care system.



Dates and versions

hal-02942701 , version 1 (18-09-2020)



Patrick Castel, Sylvie Négrier, Jean-Pierre Boissel. Why don’t cancer patients enter clinical trials? A review. European journal of cancer, 2006, 42 (12), pp.1744 - 1748. ⟨10.1016/j.ejca.2005.10.033⟩. ⟨hal-02942701⟩
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